Portland (30-33) used a 24-19 scoring edge over the final nine minutes to seal the win. The Trail Blazers had lost three of their last four games entering Wednesday.
Robert Williams III had 20 points and 11 rebounds for Portland. Memphis got double-figure scoring from seven players, including Jaylen Wells with 24 points, but it wasn't enough as they lost their second straight game. Ja Morant missed his 18th straight game due to a left elbow injury.