Trey Kaufman-Renn scored 20 points while Braden Smith added 15 points and eight assists to lead the Boilermakers. Fletcher Loyer and Omer Mayer each contributed 18 points as Purdue dominated from start to finish, extending their lead to as many as 31 points.
The victory comes three days after Purdue lost to top-ranked Michigan and could be the final meeting in Indiana for Purdue's three senior starters—Kaufman-Renn, Smith, and Loyer. Indiana was led by Lamar Wilkerson's 20 points, with 18 coming in the second half.