Scott McTominay and Billy Gilmour's chances of a second Italian title in a row could depend on Napoli downing in-form Atalanta on Sunday - and you can watch the action live on the BBC.
The second of our live games from Serie A featuring Scotland internationals kicks off at 14:00 GMT, with coverage on BBC Alba, iPlayer and the BBC Sport website and app starting at 13:50.
McTominay and Gilmour's reigning champions head to Bergamo, having fallen 11 points adrift of leaders Internazionale - and four behind AC Milan - and are praying the former can return from two games out through injury.
Gilmour made his own first appearance since November, when he picked up an injury in a 0-0 draw with Como, as a 78th-minute substitute in Sunday's 2-2 draw at home to fourth-placed Roma.
But it was fellow midfielder McTominay's turn to miss that game - and last Tuesday's penalty shoot-out defeat after a 1-1 draw at home to Como in the Coppa Italia quarter-finals.
Such is the importance of last season's Serie A player of the year and Ballon d'Or nominee that Napoli have now not won any of the three games McTominay has missed this season, losing two of them.
The Lancaster-born 29-year-old told Corriere dello Sport: "I still don't know if I'll play on Sunday. I have a tendon problem that needs to be managed; it's not easy.
"I'm giving it my all to be there. As a player, it's tough to get to the training centre and not be able to train with your team-mates. I desperately want to play, but you have to be sure of my condition."
McTominay, who has 67 Scotland caps, at least seemed to end some off-the-field uncertainty about his future with Napoli.
His form since his 2024 sale by Manchester United has consistently led to speculation about a return to the Premier League, with his former club and Tottenham linked with interest amid suggestions he had found it difficult to settle in Italy.
However, he revealed: "My agent hasn't told me anything about my future. He only talks to the club and me. He has told the press nothing.
"I'm extremely happy here, I'm a Napoli player and it's all I'm thinking about. I could see myself here for a long time.
"I love this place. Difficulties have been minimal, my family is happy and I'm happy."
Napoli appear to be happy too, with reports in Italy suggesting they are keen to extend the contract of a player who has provided 23 goals and 10 assists in 70 appearances for the club.
McTominay has blossomed in the more attacking role handed him by head coach Antonio Conte.
"At Napoli, I've grown both from a tactical point of view and a physical one," he said. "Tactically, Italy is different from the Premier League. I had to adapt and learn very quickly how to play, what movements to make... how to become a problem in the opponent's area and also how to defend.
"Antonio is a great coach, very strong, passionate, he knows football very well. He is different from anyone else I have had in the past."
McTominay points to Napoli's lengthy injury list as one of the reasons why they have slipped further behind the leaders in recent weeks but is not giving up on the title just yet.
Should he miss out on Sunday, it will increase the chances of 24-year-old Gilmour making only his seventh start in 14 appearances this season as he looks to gain game time and add to his own 43 caps at this summer's World Cup.
With only three wins in 11 outings, nine of them in Serie A, Napoli cannot afford any more slip-ups if they are to retain the Scudetto.
Hosts Atalanta lost 2-0 away to Borussia Dortmund in the first leg of their Champions League knockout stage play-off on Tuesday and lost November's reverse fixture 3-1 at Napoli, who also won 3-2 on their last visit in January, with McTominay scoring one of the goals.
However, Raffaele Palladino's side have won three in a row domestically, are unbeaten in eight in Serie A since losing at home to leaders Inter at the end of December and are only now eight points adrift of Napoli in seventh.
The meeting of the sides who finished third and first last season is poised to be a cracker live on the BBC.
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