The Yankees rolled to a 7-0 victory over the Giants at Oracle Park, scoring five runs in the second inning. Jose Caballero's single drove in a run, while Trent Grisham hit a two‑run triple and Giancarlo Stanton and Jazz Chisholm Jr. added RBI hits.
Reigning MVP Aaron Judge went 0‑4, striking out in his first four at‑bats, the first time a reigning MVP has struck out four times in a season opener. The contest also featured the debut of the Automatic Ball‑Strike system, which confirmed a fourth‑inning strike called on Logan Webb.